Table 3.
Gene regions with correlation between methylation level and relapse-free survival in ALL
| ALL subtype a | Gene symbol | Gene name | Chromosome | Number of DMCs b |
|---|---|---|---|---|
| t(12;21)ETV6/RUNX1 |
ERVH-3 |
Endogenous retrovirus group H, member 3 |
6q12 |
11 |
| |
C1orf222 |
Chromosome 1 open reading frame 222 |
1p36.33 |
2 |
| |
KCNA3 |
Potassium voltage-gated channel, shaker-related subfamily, member 3 |
1p13.3 |
2 |
| |
PAG1 |
Phosphoprotein associated with glycosphingolipid microdomains 1 |
8q21.13 |
2 |
| |
DNMBP |
Dynamin binding protein |
10q24.31 |
2 |
| |
C11orf52 |
Chromosome 11 open reading frame 52 |
11q23.1 |
2 |
|
MLL/11q23 |
ZSCAN18 |
Zinc finger and SCAN domain containing 18 |
19q13.43 |
4 |
| |
ZNF544 |
Zinc finger protein 544 |
19q13.43 |
4 |
| |
TAPBP/DAXX |
TAP binding protein (tapasin)/death-domain associated protein |
6p21.3 |
3 |
| |
WT1 |
Wilms tumor 1 |
11p13 |
3 |
| |
ZNF681 |
Zinc finger protein 681 |
19p12 |
3 |
| |
ADARB2 |
Adenosine deaminase, RNA-specific, B2 (non-functional) |
10p15.3 |
2 |
| |
ZNF329 |
Zinc finger protein 329 |
19q13.31 |
2 |
| |
ZNF526 |
Zinc finger protein 526 |
19q13.31 |
2 |
| t(9;22)BCR/ABL1 | LOC146880 | Pri-miRNA; hsa-mir-6080 (ENSG00000215769) | 17q24.1 | 2 |
aBCP ALL cytogenetic subtypes with subtype-specific differentially methylated CpGs (DMCs) predictive of relapse (P < 0.1).
bNumber of sites in the region associated with relapse-free survival (P <0.05).