Table 5. Risk of susceptibility to IgAN based on quartiles of wGRS.
| GRS | Group | IgAN | Controls | OR | 95% CI | P | P trend | ||
|---|---|---|---|---|---|---|---|---|---|
| Mean GRS | N (%) | Mean GRS | N (%) | ||||||
| wGRS5 | Q1 | −2.30 | 125(10.5) | −2.36 | 180(20.0) | 1 | |||
| Q2 | −1.42 | 287(24.1) | −1.44 | 261(29.0) | 1.58 | 1.19–2.10 | 1.42 × 10−3 | ||
| Q3 | −0.59 | 295(24.8) | −0.58 | 225(25.0) | 1.89 | 1.42–2.52 | 1.26 × 10−5 | ||
| Q4 | −0.11 | 383(40.6) | −0.14 | 233(25.9) | 2.37 | 1.79–3.13 | 1.16 × 10−9 | 3.13 × 10−16 | |
| wGRS7 | Q1 | −2.59 | 135(11.3) | −2.74 | 202(22.5) | 1 | |||
| Q2 | −1.69 | 270(22.7) | −1.73 | 242(26.9) | 1.67 | 1.26–2.21 | 2.97 × 10−4 | ||
| Q3 | −0.96 | 249(20.9) | −0.97 | 202(22.5) | 1.84 | 1.39–2.46 | 2.56 × 10−5 | ||
| Q4 | −0.34 | 536(45.0) | −0.41 | 253(28.1) | 3.17 | 2.43–4.13 | 2.57 × 10−18 | 9.38 × 10−19 | |
| wGRS9 | Q1 | −2.87 | 147(12.4) | −3.02 | 223(24.8) | 1 | |||
| Q2 | −1.98 | 250(21.0) | −2.00 | 226(25.1) | 1.68 | 1.27–2.21 | 2.17 × 10−4 | ||
| Q3 | −1.25 | 297(25.0) | −1.26 | 225(25.0) | 2.00 | 1.53–2.63 | 4.37 × 10−7 | ||
| Q4 | −0.59 | 496(41.7) | −0.68 | 225(25.0) | 3.34 | 2.58–4.34 | 2.51 × 10−20 | 9.81 × 10−21 | |
| wGRS4 | Q1 | −1.10 | 178(15.0) | −1.15 | 218(24.2) | 1 | |||
| Q2 | −0.75 | 229(19.2) | −0.75 | 216(24.0) | 1.30 | 0.99–1.70 | 0.06 | ||
| Q3 | −0.56 | 247(20.8) | −0.56 | 177(19.7) | 1.71 | 1.30–2.25 | 1.39 × 10−4 | ||
| Q4 | −0.28 | 536(45.0) | −0.31 | 288(32.0) | 2.28 | 1.79–2.91 | 2.53 × 10−11 | 9.04 × 10−13 | |
| Standardized GRS | Q1 | −0.75 | 133(11.2) | −0.85 | 224(24.9) | 1 | |||
| Q2 | 0.15 | 228(19.2) | 0.11 | 216(24.0) | 1.78 | 1.34–2.36 | 6.74 × 10−5 | ||
| Q3 | 0.78 | 302(25.4) | 0.75 | 217(24.1) | 2.34 | 1.78–3.09 | 1.14 × 10−9 | ||
| Q4 | 1.57 | 527(44.3) | 1.48 | 242(26.9) | 3.67 | 3.82–4.77 | 3.57 × 10−23 | 3.54 × 10−24 | |
We calculated the odds for the top group (Q4) compared with the bottom group (Q1) as the reference group.