Table 2. DRB1 and DQB1 alleles in patients with fulminant type 1 diabetes and control subjects.
| Fulminant | Control (n = 650†) | Total vs control | GADab(+) vs control | GADab(–) vs control | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Total (n = 414†) | GADab(+) (n = 50†) | GADab(−) (n = 364†) | |||||||||
| n (%) | n (%) | n (%) | n (%) | Pc | OR | Pc | OR | Pc | OR | ||
| DRB1 | *01:01 | 9 (2.2) | 0 (0.0) | 9 (2.5) | 50 (7.7) | 2.8 × 10−3 | 0.27 | NS | 0.015 | 0.30 | |
| *04:01 | 6 (1.4) | 1 (2.0) | 5 (1.4) | 5 (0.8) | NS | NS | NS | ||||
| *04:03 | 6 (1.4) | 1 (2.0) | 5 (1.4) | 21 (3.2) | NS | NS | NS | ||||
| *04:05 | 135 (32.6) | 11 (22.0) | 124 (34.0) | 92 (14.2) | 1.7 × 10−11 | 2.9 | NS | 2.4 × 10−12 | 3.1 | ||
| *04:06 | 3 (0.7) | 1 (2.0) | 2 (0.5) | 23 (3.5) | NS | NS | NS | ||||
| *04:07 | 1 (0.2) | 0 (0.0) | 1 (0.3) | 5 (0.8) | NS | NS | NS | ||||
| *04:10 | 13 (3.1) | 0 (0.0) | 13 (3.6) | 9 (1.4) | NS | NS | NS | ||||
| *08:02 | 14 (3.4) | 2 (4.0) | 12 (3.3) | 30 (4.6) | NS | NS | NS | ||||
| *08:03 | 13 (3.1) | 1 (2.0) | 12 (3.3) | 58 (8.9) | 5.0 × 10−3 | 0.33 | NS | 0.015 | 0.35 | ||
| *09:01 | 106 (25.6) | 22 (44.0) | 84 (23.1) | 90 (13.8) | 3.1 × 10−5 | 2.1 | 4.6 × 10−7 | 4.9 | 4.1 × 10−3 | 1.9 | |
| *10:01 | 1 (0.2) | 0 (0.0) | 1 (0.3) | 9 (1.4) | NS | NS | NS | ||||
| *11:01 | 3 (0.7) | 0 (0.0) | 3 (0.8) | 13 (2.0) | NS | NS | NS | ||||
| *12:01 | 7 (1.7) | 1 (2.0) | 6 (1.6) | 27 (4.2) | NS | NS | NS | ||||
| *12:02 | 5 (1.2) | 2 (4.0) | 3 (0.8) | 9 (1.4) | NS | NS | NS | ||||
| *13:02 | 23 (5.6) | 1 (2.0) | 22 (6.0) | 26 (4.0) | NS | NS | NS | ||||
| *14:01 | 7 (1.7) | 1 (2.0) | 6 (1.6) | 23 (3.5) | NS | NS | NS | ||||
| *14:03 | 1 (0.2) | 0 (0.0) | 1 (0.3) | 6 (0.9) | NS | NS | NS | ||||
| *14:05 | 3 (0.7) | 0 (0.0) | 3 (0.8) | 12 (1.8) | NS | NS | NS | ||||
| *14:06 | 3 (0.7) | 0 (0.0) | 3 (0.8) | 7 (1.1) | NS | NS | NS | ||||
| *15:01 | 22 (5.3) | 3 (6.0) | 19 (5.2) | 45 (6.9) | NS | NS | NS | ||||
| *15:02 | 16 (3.9) | 0 (0.0) | 16 (4.4) | 73 (11.2) | 5.1 × 10−4 | 0.32 | NS | 4.9 × 10−3 | 0.36 | ||
| *16:02 | 8 (1.9) | 2 (4.0) | 6 (1.6) | 6 (0.9) | NS | NS | NS | ||||
| Others | 9 (2.2) | 1 (2.0) | 8 (2.2) | 11 (1.6) | |||||||
| DQB1 | *03:01 | 18 (4.3) | 3 (6.0) | 15 (4.1) | 62 (9.5) | 0.019 | 0.43 | NS | 0.020 | 0.41 | |
| *03:02 | 21 (5.1) | 2 (4.0) | 19 (5.2) | 67 (10.3) | 0.028 | 0.46 | NS | NS | |||
| *03:03 | 109 (26.3) | 22 (44.0) | 87 (23.9) | 97 (14.9) | 4.9 × 10−5 | 2.0 | 1.5 × 10−6 | 4.5 | 4.1 × 10−3 | 1.8 | |
| *04:01 | 133 (32.1) | 11 (22.0) | 122 (33.5) | 91 (14.0) | 1.7 × 10−11 | 2.9 | NS | 2.8 × 10−12 | 3.1 | ||
| *04:02 | 22 (5.3) | 2 (4.0) | 20 (5.5) | 27 (4.2) | NS | NS | NS | ||||
| *05:01 | 11 (2.7) | 0 (0.0) | 11 (3.0) | 59 (9.1) | 4.2 × 10−4 | 0.27 | NS | 2.9 × 10−3 | 0.31 | ||
| *05:02 | 11 (2.7) | 3 (6.0) | 8 (2.2) | 19 (2.9) | NS | NS | NS | ||||
| *05:03 | 8 (1.9) | 1 (2.0) | 7 (1.9) | 23 (3.5) | NS | NS | NS | ||||
| *06:01 | 30 (7.2) | 1 (2.0) | 29 (8.0) | 132 (20.3) | 8.1 × 10−8 | 0.31 | 0.030 | 0.08 | 2.7 × 10−6 | 0.34 | |
| *06:02 | 21 (5.1) | 3 (6.0) | 18 (4.9) | 44 (6.8) | NS | NS | NS | ||||
| *06:04 | 20 (4.8) | 1 (2.0) | 19 (5.2) | 26 (4.0) | NS | NS | NS | ||||
| Others | 10 (2.4) | 1 (2.0) | 9 (2.5) | 4 (0.6) | |||||||
GADab, antibodies to glutamic acid decarboxylase; NS, not significant.
Pc‐, P‐values corrected for number of different alleles tested (×22 for DRB1and ×11 for DQB1).
†Allele number.