Table 4.  Predictors of glucagon like polypeptide‐1 (GLP‐1) and glucose‐dependent insulinotropic polypeptide (GIP) secretion (area under the curve total glucagon like polypeptide‐1 and area under the curve total glucose‐dependent insulinotropic polypeptide) after meal ingestion.

	AUC‐GLP‐1 (pmol/L × min)						AUC‐GIP (pmol/L × min)
	All		No drug		SU		All		No drug		SU
	r	P	r	P	r	P	r	P	r	P	R	P
Age (years)	−0.168	0.294	−0.181	0.409	0.344	0.163	0.274	0.083	0.021	0.925	0.374	0.127
Duration of diabetes (years)	−0.291	0.065	−0.221	0.302	−0.223	0.373	0.060	0.708	0.179	0.798	−0.327	0.185
BMI (kg/m2)	−0.04	0.806	0.096	0.660	−0.241	0.336	0.058	0.720	−0.191	0.384	0.008	0.993
HbA1c (%)	0.425	0.006	0.682	<0.001	−0.285	0.251	0.256	0.109	0.257	0.237	0.150	0.553
HOMA‐IR	−0.107	0.505	0.221	0.311	−0.098	0.698	−0.073	0.650	−0.342	0.110	−0.132	0.601
HOMA‐β	−0.278	0.078	−0.228	0.295	−0.090	0.722	−0.006	0.969	−0.564	0.005	0.068	0.787
SUIT	−0.089	0.582	−0.174	0.428	−0.032	0.899	−0.004	0.981	−0.518	0.011	0.190	0.451
Fasting plasma glucose (mg/dL)	0.001	0.993	0.437	0.037	−0.044	0.863	0.003	0.983	0.331	0.122	−0.176	0.486
AUC‐plasma glucose (mg/dL × min)	0.032	0.845	0.643	0.001	0.231	0.357	0.308	0.050	0.538	0.008	0.107	0.674
Fasting glucagon (pg/mL)	0.111	0.491	−0.001	0.911	0.345	0.160	−0.079	0.622	−0.317	0.140	0.107	0.671
AUC‐glucagon (pg/mL × min)	0.056	0.726	−0.065	0.770	0.361	0.141	0.052	0.747	−0.244	0.263	0.244	0.330
Fasting insulin (mU/L)	−0.193	0.227	0.071	0.746	−0.062	0.808	−0.061	0.704	−0.457	0.028	−0.054	0.832
AUC‐insulin (mU/L × min)	0.147	0.359	−0.070	0.749	0.225	0.216	0.037	0.819	−0.269	0.214	0.067	0.790
Fasting C‐peptide (ng/mL)	0.078	0.628	0.071	0.747	0.103	0.683	−0.127	0.427	−0.400	0.059	−0.012	0.961
AUC‐C‐peptide (ng/mL × min)	0.049	0.761	−0.021	0.925	0.544	0.020	−0.026	0.874	−0.304	0.159	0.135	0.593
Fasting FFA (mEq/L)	0.526	<0.001	0.598	0.003	−0.233	0.352	−0.096	0.550	0.111	0.614	−0.310	0.211
DPP‐4 (nmol/min/mL)	−0.422	0.006	−0.547	0.007	−0.030	0.906	0.162	0.311	0.132	0.549	0.080	0.752
Fasting GLP‐1 (pmol/L)	0.633	<0.001	0.654	<0.001	0.579	0.008	0.087	0.588	0.035	0.873	−0.143	0.579
Fasting GIP (pmol/L)	−0.008	0.962	−0.054	0.807	−0.324	0.164	0.538	<0.001	0.284	0.179	0.326	0.548
AUC‐GIP (pmol/L × min)	0.128	0.426	−0.205	0.3484	−0.287	0.248	–	–	–	–	–	–

AUC, area under curve; BMI, body mass index; CPR, C‐peptide reactivity; DPP, dipeptidyl peptidase; FFA, free fatty acid; GIP, glucose‐dependent insulinotropic polypeptide; GLP‐1, glucagon like polypeptide‐1; HOMA, homeostatic model assessment; IR, insulin resistance; SUIT, secretory unit of islet in transplantation. P values were calculated by linear regression analysis; r, correlation coefficient. All, both anti‐diabetic drug‐naïve patients and sulfonylureas‐treated patients; No drug, anti‐diabetic drug‐naïve patients; and SU, sulfonylureas‐treated patients.