Table 5.
Levels of soluble intercellular adhesion molecule-1 in neonates, children and adults
| Study (reference) | Mean age | Sepsis criteria | Healthy (μg/ml) a | Number of patients (healthy) | Sepsis (μg/ml) a | Number of patients (sepsis) |
|---|---|---|---|---|---|---|
|
Neonates |
|
|
|
|
|
|
| Figueras-Aloy and colleagues [49] |
0 to 14 days |
SNAP-II |
215 (156 to 274) |
12 |
426 (394 to 458) |
15 |
| Apostolou and colleagues [58] |
At term |
Clinical |
358.4 ± 28.9 |
10 |
710.7 ± 56.6 |
10 |
| Dollner and colleagues [52] |
0 to 7 days |
Clinical |
244 (95.2 to 500) |
24 |
413 (255.6 to 500) |
18 |
| Austgulen and colleagues [45] |
Pre/at term |
Clinical |
258.8 (94 to 500) |
168 |
394.2 (197.5 to 500) |
24 |
| Berner and colleagues [51] |
0 to 3 days |
Clinical |
421 (291 to 459) |
35 |
446 (171 to 534) |
136 |
| Edgar and colleagues [57] |
0 to 7 days |
Clinical |
165 (130 to 290) |
27 |
341 (236 to 554) |
192 |
| Edgar and colleagues [56] |
0 to 7 days |
Clinical |
205 |
46 |
406 |
46 |
|
Children |
|
|
|
|
|
|
| Andrys and colleagues [60] |
6 to 10 |
|
346.8 (206.8 to 486.8) |
68 |
|
|
| |
11 to 15 |
|
269 (184.1 to 354) |
90 |
|
|
| Paize and colleagues [61] |
2 to 16 |
PRISM |
260 (240 to 300) |
40 |
705 (400 to 850) |
20 |
| Whalen and colleagues [63] |
1 day to 17 years |
Criteria of Doughty and colleaguesb |
205 ± 29 |
14 |
595 |
77 |
| Nash and colleagues [64] |
9 |
|
310 (280 to 410) |
81 |
|
|
| |
15 |
|
300 (270 to 390) |
|
|
|
| Briassoulis and colleagues [19] |
6.5 (2.8) |
PRISM |
199 ± 98 |
10 |
172 ± 93 |
10 |
|
Adults |
|
|
|
|
|
|
| Weigand and colleagues [66] |
58.7 (4.4) |
ACCP/SCCM |
190 |
7 |
1,100 |
14 |
| Soderquist and colleagues [70] |
71 (10 to 91) |
Unknown |
202 (62 to 392) |
15 |
451 (216 to 1,030) |
41 |
| Scherpereel and colleagues [77] |
58.9 (14.9) |
SAPS II |
|
|
2,130 |
63 |
| Hofer and colleagues [78] |
65.9 (12.4) |
APACHE II |
219.6 (195.2 to 285.1) |
108 |
444.7 (330 to 665.5) |
18 |
| De Pablo and colleagues [73] |
61.2 (3.2) |
APACHE II |
480 |
36 |
1100 |
52 |
| Kayal and colleagues [74] |
57.2 (3.9) |
ACCP/SCCM |
208 ± 20.5 |
9 |
868 ± 131 |
25 |
| Shapiro and colleagues [6] |
57 (19) |
APACHE III |
185 |
207 |
240 |
13 |
| Andrys and colleagues [60] |
46 |
|
140 (60.2 to 218.4) |
68 |
|
|
| Leone and colleagues [76] | 45 to 47 (16 to 21) | SIRS | 151 | 26 | 824 | 11 |
ACCP/SCCM, American college of chest physicians/ society of critical care medicine; APACHE, acute physiology and chronic health evaluation; PRISM, pediatric risk of mortality; SAPS, simplified acute physiology score; SIRS, systemic inflammatory response syndrome; SNAP, score for neonatal acute physiology. aData presented as mean (range) or mean ± standard deviation. bCriteria from [75]. Ages expressed in years unless otherwise stated.