Table 1.
Assessment of FeNO in ECOPD
| Ref. | Course: | At ECOPD onset | Course: | Comment | |
|---|---|---|---|---|---|
| |
From Baseline to |
FeNO levels |
Comparisons |
After ECOPD |
|
| |
ECOPD Onset |
(ppb) |
|
onset |
|
| Agusti et al. [10] |
|
€41.0 ± 5.1, † 5.7-76.5 |
ECOPD > controls |
↓ |
GCS. ↓ by M1-2 or by M6-8 |
| Al-Ali et al. [11] |
|
£10.3 (2.7-34) |
↔ECOPD, controls, pneumonia |
|
|
| ↔ECOPD smokers, ex smokers | |||||
| Antus et al. [12] |
|
¥25.3 (21.2–30.1) |
|
↓ |
GCS. ↓ by discharge |
| Antus et al. [13] |
|
¥23.8 (19.4–29.7) |
↔ECOPD smokers, ex smokers |
↓ |
↓ by discharge |
| Bhowmik et al. [14] |
↑* |
#7.40 (4.80–9.60) |
|
↓* |
Exact time points N/R |
| Cosio et al. [15] |
|
N/R |
|
↓ |
GCS. ↓ by M3 |
| Kersul et al. [16] |
|
N/R |
N/R |
↓ |
GCS. ↓ by M3 after discharge |
| Lazar et al. [17] |
|
‡10 (7) |
↔ECOPD, controls (non-smokers, smokers) |
N/R |
Time points: admission, discharge |
| Papi et al. [18] | €15.18 ±1.85 | ↓ | GCS. ↓ by W8-10 | ||
The columns concerning the course of FeNO refer to longitudinal studies (paired samples) and the column concerning comparisons at ECOPD onset refers to cross-sectional studies (unpaired samples).
Abbreviations: D day after ECOPD onset, FeNO fraction of exhaled nitric oxide, GCS administration of systemic glucocorticosteroids, M months after ECOPD onset, N/R not reported, ppb parts per billion, W weeks after ECOPD onset.
Symbols: ↔: no difference, ↑: increase, ↓: decrease, € mean ± SEM, † range, £ median (range), ¥ geometric mean (95% CI), # Median (interquartile range), ‡ mean (SD), *: stability samples obtained before and after the ECOPD.