Table 1.
BAL cytokine level comparisons between 2- and 6-month-old mice after a one-week PBS or OVA challenge
| |
|
WT |
Cav1
-/-
|
||
|---|---|---|---|---|---|
| Challenge | PBS | OVA | PBS | OVA | |
| 2 M old |
IL-4 |
10.5 ± 2 |
921 ± 446* |
16 ± 7 |
1273 ± 1251### |
| IL-5 |
94 ± 7 |
1711 ± 2596 |
128 ± 34 |
4434 ± 7265 |
|
| IL-9 |
13 ± 3 |
31 ± 12*** |
16 ± 3 |
25 ± 11 |
|
| IL-13 |
19.5 ± 9.5 |
122 ± 95 |
15 ± 5 |
129 ± 180** |
|
| IL-17 |
36.5 ± 2 |
63 ± 24 |
38 ± 4 |
59 ± 24 |
|
| IgE |
0 |
42 ± 74 |
0 |
49 ± 85 |
|
| 6 M old | IL-4 |
75 ± 13 |
341 ± 244 |
71 ± 10 |
520 ± 780 |
| IL-5 |
22 ± 3 |
903 ± 176 |
21 ± 5 |
542 ± 788 |
|
| IL-9 |
27 ± 3.5† |
24 ± 14 |
24 ± 5 |
21 ± 5 |
|
| IL-13 |
34 ± 5.5 |
176 ± 121** |
36 ± 5 |
45 ± 21## |
|
| IL-17 |
84 ± 19 |
96 ± 16 |
82 ± 8 |
67 ± 14 ## |
|
| IgE | 0 | 1.8 ± 1.3 | 0 | 53 ± 68.9 | |
*p < 0.05, **p < 0.01, ***p < 0.001 between PBS- and OVA-challenged mice. ##p < 0.01 ###p < 0.001 between Cav1-/- and WT mice, †p < 0.05 between 2- and 6-month old mice. n = 6-12. Values are ng/ml ± standard deviation. Significance determined by one-way ANOVA with a Tukey post test.