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Effects of icv injection of mefloquine (50, 100, 200 μg/rat) on the expression of naloxone (4 mg/kg)-induced TWS in morphine-dependent rats. Data are expressed as mean ± S.E.M. ***p < 0.001 different from control (morphine-dependent DMSO 25% microinjected group). M = Morphine, S = Saline, MFQ = Mefloquine.
