Table 1.
Results of MSEA in a comparative study of normal and 12 h-fasted mice
| |
ORA |
Subramanian's approach |
||||||
|---|---|---|---|---|---|---|---|---|
| |
Positive correlation with PC1 |
Negative correlation with PC1 |
Positive correlation with PC1 |
|||||
| p-value | q-value | p-value | q-value | NES | p-value | q-value | ||
| Glycolysis |
1.0000 |
1.0000 |
0.0001* |
0.0036** |
-2.0048 |
0.0000* |
0.0074** |
|
| Pentose phosphate pathway |
1.0000 |
1.0000 |
0.0308* |
0.2000 |
-1.6040 |
0.0283* |
0.1781 |
|
| TCA cycle |
1.0000 |
1.0000 |
0.0040* |
0.0519 |
-1.6208 |
0.0165* |
0.2433 |
|
| Glutamic acid and glutamine metabolism |
1.0000 |
1.0000 |
0.4901 |
0.9801 |
-1.0936 |
0.3497 |
0.5193 |
|
| Alanine, aspartic acid and asparagine metabolism |
0.8254 |
1.0000 |
0.2878 |
0.8313 |
-1.1897 |
0.2625 |
0.4379 |
|
| Lysine metabolism |
0.8567 |
1.0000 |
0.8681 |
1.0000 |
-0.8172 |
0.7078 |
0.8274 |
|
| Valine, leucine and isoleucine metabolism |
1.0000 |
1.0000 |
0.7735 |
1.0000 |
-0.9392 |
0.5636 |
0.7311 |
|
| Glycine, serine and threonine metabolism |
0.7434 |
1.0000 |
0.0720 |
0.2445 |
-1.2557 |
0.1803 |
0.3704 |
|
| Cysteine metabolism |
0.6489 |
1.0000 |
0.0412* |
0.2142 |
-1.3259 |
0.1611 |
0.3371 |
|
| Methionine metabolism |
0.6178 |
1.0000 |
0.8444 |
1.0000 |
0.8697 |
0.6147 |
0.7197 |
|
| Shikimic acid metabolism |
1.0000 |
1.0000 |
0.4901 |
0.9801 |
-1.2676 |
0.1745 |
0.3901 |
|
| Histidine metabolism |
0.5434 |
1.0000 |
1.0000 |
1.0000 |
1.8978 |
0.0080* |
0.0520 |
|
| Urea cycle |
0.8567 |
1.0000 |
0.0507 |
0.2197 |
-1.3352 |
0.1524 |
0.3705 |
|
| Proline metabolism |
1.0000 |
1.0000 |
0.6001 |
1.0000 |
-1.1524 |
0.3041 |
0.4619 |
|
| Polyamine metabolism |
1.0000 |
1.0000 |
0.0308* |
0.2000 |
-1.5785 |
0.0309* |
0.1581 |
|
| Tryptophan metabolism |
0.7413 |
1.0000 |
0.9269 |
1.0000 |
-0.7141 |
0.8260 |
0.8764 |
|
| Tyrosine metabolism |
1.0000 |
1.0000 |
0.0752 |
0.2445 |
-1.3601 |
0.1176 |
0.3820 |
|
| beta-alanine metabolism |
0.2111 |
1.0000 |
0.8616 |
1.0000 |
0.9218 |
0.5531 |
0.7578 |
|
| Taurine metabolism |
1.0000 |
1.0000 |
0.3721 |
0.9675 |
-1.4114 |
0.1010 |
0.3535 |
|
| Creatine metabolism |
0.7874 |
1.0000 |
0.4705 |
0.9801 |
-0.8041 |
0.7093 |
0.7984 |
|
| Purine metabolism |
0.0285* |
0.7411 |
0.9983 |
1.0000 |
1.6391 |
0.0220* |
0.1290 |
|
| Pyrimidine metabolism |
0.9649 |
1.0000 |
0.9860 |
1.0000 |
0.7965 |
0.7355 |
0.7258 |
|
| Ribonucleotide metabolism |
0.3473 |
1.0000 |
1.0000 |
1.0000 |
1.1184 |
0.2800 |
0.6998 |
|
| Deoxyribonucleotide |
1.0000 |
1.0000 |
1.0000 |
1.0000 |
-0.6743 |
0.9776 |
0.8725 |
|
| Conjugated bile acid |
0.5361 |
1.0000 |
1.0000 |
1.0000 |
1.0384 |
0.3671 |
0.6834 |
|
| Nicotinic acid metaboilsm | 0.3473 | 1.0000 | 0.5357 | 0.9949 | -0.8360 | 0.6536 | 0.8510 | |
*p < 0.05, **q < 0.05.