Table 3.

First-line drugs used for treatment of tuberculosis in childhood [1,9,12,13,24,27-31]

	Daily dosage (maximum dosage)	Twice-thrice weekly dosage (maximum dosage)	Adverse Reactions
Isoniazid (INH)	10-15 mg/kg (300 mg)	20-30 mg/kg (900 mg)	Hepatotoxic effects , such as mild hepatic enzyme elevation and hepatitis, gastritis, peripheral neuropathy, hypersensitivity
Rifampicin (RIF)	10-20 mg/kg (600 mg)	10-20 mg/kg (600 mg)	Orange discoloration of secretions and urine, vomiting, hepatitis, influenza-like reaction, thrombocytopenia
Pyrazinemide (PZA)	30-40 mg/kg (2 g)	50 mg/kg (2 g)	Hepatotoxic effects, hyperuricemia, arthralgia, gastrointestinal tract disturbances
Ethambutol (EMB)	15-25 mg/kg (2,5 g)	50 mg/kg (2,5 g)	Optic neuritis with decreased red-green colour discrimination and visual acuity, gastrointestinal disturbances, hypersensitivity