Table.
Comparison of Demographics, Symptomatology, Endoscopic and Histological Findings Between Anti-deamidated Gliadin Peptide IgA Positive and Negative Irritable Bowel Syndrome Patients
| IgA DGP (+) (n = 34) | IgA DGP (–) (n = 152) | P-value | |
|---|---|---|---|
| Age (mean [SD], yr) | 42.5 (10.8) | 43.0 (12.9) | 0.589 |
| Female (n [%]) | 24 (71) | 75 (49) | 0.025 |
| Male:Female | 10:24 | 77:75 | |
| Prevalence of IgA DGP by ethnic group (n [%]) | |||
| Chinese (n = 124) | 21 (17) | 103 (83) | 0.548 |
| Indonesian (n = 17) | 7 (41) | 10 (59) | 0.018 |
| Indian (n = 37) | 5 (14) | 32 (86) | 0.483 |
| Eurasian (n = 5) | 1 (20) | 4 (80) | 1.000 |
| Others (n = 3) | 0 (0) | 3 (100)a | - |
| Symptoms at presentation (n [%]) | |||
| Abdominal pain | 22 (65) | 125 (82) | 0.023 |
| Bloating | 25 (74) | 125 (82) | 0.245 |
| Constipation | 10 (29) | 45 (30) | 0.982 |
| Diarrhea | 16 (47) | 70 (46) | 0.915 |
| Belching | 21 (62) | 85 (56) | 0.534 |
| Flatulence | 15 (44) | 107 (70) | 0.004 |
| Vomiting | 1 (3) | 2 (1) | 0.496 |
| Most bothersome symptom (n [%]) | |||
| Abdominal pain | 10 (29) | 62 (41) | 0.25 |
| Bloating | 7 (21) | 46 (30) | 0.30 |
| Constipation | 2 (6) | 7 (5) | 0.67 |
| Diarrhea | 10 (29) | 19 (12) | 0.02 |
| Belching | 2 (6) | 7 (5) | 0.67 |
| Flatulence | 2 (6) | 8 (5) | 1.00 |
| Other symptoms | 1 (3)b | 3 (2)c | NA |
| Endoscopic and histological findings (n [%]) | |||
| H. pylori (+) | 6 (18) | 47 (31) | 0.112 |
| Villous blunting | 15 (44) | 42 (28) | 0.059 |
| IEL | 10 (29) | 14 (9) | 0.001 |
a
These 3 patients are Japanese, Korean and Vietnamese, respectively;
b
Choking sensation;
c
Nausea, loss of weight and headache, respectively.
IgA DGP, anti-deamidated gliadin peptide IgA antibodies; IEL, intra-epithelial lymphocytosis; NA, not applicable.
Villous blunting = villous to crypt ratio of < 3:1. Intra-epithelial lymphocytosis = more than 10 lymphocytes per 100 enterocytes.
All P-values were calculated using Fisher’s exact test.