FIG. 5.

Enhancement of lung gene expression in mice requires a 60-min exposure to nebulized perflubron. Shown are representative low-magnification (×100) overviews, corresponding high-magnification detailed views (×400), and further enlargements of selected areas in the×400 magnifications of lungs from mice receiving intratracheal instillation of AdlacZ alone (Ad), AdlacZ instillation 6 hr after a 15-min exposure to nebulized perflubron (15 min neb), AdlacZ instillation 6 hr after a 30-min exposure to nebulized perflubron (30 min neb), or AdlacZ instillation 6 hr after a 60-min exposure to nebulized perflubron (1 hr neb). n=4–11 for each experimental condition. Color images available online at www.liebertpub.com/hgtb