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. 2014 Mar 4;22(5):986–998. doi: 10.1038/mt.2014.7

Figure 2.

Figure 2

Comparative cytotoxicity of canine viruses in four canine tumor cell lines. Infection with the indicated viruses, at doses ranging from 2,000 to 0.01 transducing units (tu)/cell for Abrams, CML1, and 17CM98 or from 500 to 0.001 tu/cell for D17 was performed. The IC50 values (tu/cell needed to reduce by 50% the cell viability) at days 6–8 after infection are shown. Three different replicates were quantified for each cell line. Mean ± SD are plotted. IC50 →∞ for CAV2 at 17CM98 and Abrams cells indicates estimated values of IC50 over 106 tu/cell. *Significant (P < 0.05) compared to CAV2 by two-tailed unpaired Student's t-test; #Significant (P < 0.05) compared to CAV2RGD by two-tailed unpaired Student's t-test.