TABLE V. Logistic regression analysis for association between ERBB2 tagging single nucleotide polymorphisms (tag-SNPs) in cases and controls from the state of Rio Grande do Norte (RN), Brazil.
| Marker | Phenotype | Allele | Case | Control | OR | 95% CI | padj |
|---|---|---|---|---|---|---|---|
| rs2517955 | LL | C | 299/628 | 347/696 | 0.89 | 0.70-1.13 | 0.340 |
| rs2517956 | LL | A | 397/646 | 439/714 | 0.97 | 0.76-1.24 | 0.820 |
| rs1810132 | LL | C | 230/640 | 273/710 | 0.88 | 0.68-1.12 | 0.290 |
| rs2952156 | LL | A | 229/646 | 273/720 | 0.88 | 0.69-1.13 | 0.320 |
| rs1801200 | LL | A | 550/642 | 611/716 | 0.99 | 0.72-1.36 | 0.970 |
| rs1058808 | LL | C | 305/654 | 357/720 | 0.86 | 0.68-1.09 | 0.210 |
| rs2517955 | TT | C | 211/412 | 347/696 | 0.96 | 0.75-1.23 | 0.740 |
| rs2517956 | TT | A | 243/412 | 439/714 | 1.10 | 0.86-1.41 | 0.440 |
| rs1810132 | TT | C | 163/412 | 273/710 | 1.04 | 0.81-1.34 | 0.750 |
| rs2952156 | TT | A | 166/416 | 273/720 | 1.08 | 0.84-1.39 | 0.530 |
| rs1801200 | TT | A | 348/412 | 611/716 | 1.08 | 0.77-1.50 | 0.660 |
| rs1058808 | TT | C | 201/412 | 357/720 | 0.95 | 0.74-1.21 | 0.670 |
| rs2517955 | Leprosy per se | C | 558/1136 | 347/696 | 1.03 | 0.85-1.25 | 0.758 |
| rs2517956 | Leprosy per se | A | 697/1152 | 439/714 | 1.04 | 0.86-1.26 | 0.672 |
| rs1810132 | Leprosy per se | C | 432/1146 | 273/710 | 1.03 | 0.85-1.26 | 0.742 |
| rs2952156 | Leprosy per se | A | 433/1158 | 273/720 | 1.02 | 0.84-1.24 | 0.817 |
| rs1801200 | Leprosy per se | A | 976/1144 | 611/716 | 1.00 | 0.76-1.33 | 0.991 |
| rs1058808 | Leprosy per se | C | 564/1162 | 357/720 | 1.04 | 0.86-1.26 | 0.655 |
| rs2517955 | RR | C | 113/230 | 372/758 | 1.05 | 0.71-1.55 | 0.820 |
| rs2517956 | RR | A | 139/230 | 468/776 | 0.78 | 0.52-1.17 | 0.230 |
| rs1810132 | RR | C | 84/232 | 294/770 | 0.73 | 0.48-1.12 | 0.140 |
| rs2952156 | RR | A | 85/236 | 291/774 | 0.77 | 0.51-1.17 | 0.220 |
| rs1801200 | RR | A | 206/238 | 649/764 | 0.98 | 0.59-1.65 | 0.950 |
| rs1058808 | RR | C | 116/238 | 376/780 | 0.93 | 0.63-1.38 | 0.720 |
| rs2517955 | ENL | C | 79/174 | 406/814 | 0.88 | 0.55-1.40 | 0.590 |
| rs2517956 | ENL | A | 113/180 | 498/826 | 0.93 | 0.58-1.47 | 0.740 |
| rs1810132 | ENL | C | 67/182 | 311/820 | 1.04 | 0.64-1.67 | 0.890 |
| rs2952156 | ENL | A | 63/176 | 313/834 | 1.03 | 0.64-1.68 | 0.890 |
| rs1801200 | ENL | A | 152/176 | 703/826 | 0.83 | 0.46-1.48 | 0.520 |
| rs1058808 | ENL | C | 84/182 | 408/836 | 1.02 | 0.65-1.62 | 0.920 |
logistic regression adjusted for all independent environmental covariates was used to assess association between ERBB2 tag-SNPs (Table III) and lepromatous (LL), tuberculoid (TT) or leprosy per se in case-control samples from RN. The frequencies of the alleles ( per 2n chromosomes successfully genotyped) for which odds ratios (OR) were determined are shown under the case and control columns.CI: confidence interval; ENL: erythema nodosum leprosum; RR: reversal reaction.