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Hypothetical mechanism for the origin of the G418r gancyclovirr, attR-, attL-clones generated by the serine integrases during integration reactions. The figure shows a two step model for the origin of the GANCr Neor attL- attR-clones arising during the integration experiments. A illustrates the first step in the model; the deletion of the HyTK gene and B illustrates the second step; the integration of the CCAGneo gene. Further details are discussed in the text.
