Table 4.
The genes showing the highest down-regulation of corpus expression in patients with corpus atrophy (ranked by regression coefficients)
| ID | Symbol | Description |
Corpus |
Antrum |
Fold change
b
|
Cluster c | ||||
|---|---|---|---|---|---|---|---|---|---|---|
| B a | R 2 | B a | R 2 | Hp- | Hp+ | Atr | ||||
| ILMN_25453 |
AMCase |
chitinase, acidic, transcript variant 1 |
-3.66 |
0.69 |
-0.74 |
0.04 |
93 |
97 |
2 |
C4 |
| ILMN_12978 |
MRGPRD |
MAS-related GPR, member D |
-3.32 |
0.71 |
-0.59 |
-0.04 |
103 |
100 |
2 |
C4 |
| ILMN_27134 |
CHRD |
chordin, transcript variant 2 |
-3.25 |
0.69 |
-0.87 |
0.13 |
69 |
65 |
3 |
C4 |
| ILMN_24872 |
AMCase |
chitinase, acidic, transcript variant 2 |
-3.24 |
0.69 |
-0.65 |
0.11 |
37 |
31 |
1 |
C4 |
| ILMN_16471 |
ATP4A |
ATPase, H+/K + exchanging, alpha polypeptide |
-3.03 |
0.87 |
-0.78 |
0.10 |
46 |
37 |
2 |
C4 |
| ILMN_21851 |
AQP4 |
aquaporin 4, transcript variant b |
-2.80 |
0.85 |
-0.74 |
0.14 |
27 |
25 |
2 |
C4 |
| ILMN_23805 |
AGXT2L1 |
alanine-glyoxylate aminotransferase 2-like 1 |
-2.77 |
0.93 |
-0.48 |
0.10 |
27 |
9 |
1 |
C4 |
| ILMN_11251 |
PTGER3 |
prostaglandin E receptor 3, transcript variant 9 |
-2.67 |
0.85 |
-0.58 |
0.07 |
27 |
15 |
2 |
C4 |
| ILMN_12353 |
ATP4B |
ATPase, H+/K + exchanging, beta polypeptide |
-2.60 |
0.70 |
-1.28 |
0.13 |
49 |
46 |
8 |
C4 |
| ILMN_11182 |
FGA |
fibrinogen alpha chain , transcript variant alpha |
-2.40 |
0.90 |
-0.54 |
0.10 |
20 |
12 |
2 |
C4 |
| ILMN_13882 |
FGB |
fibrinogen beta chain |
-2.39 |
0.89 |
-0.26 |
-0.03 |
31 |
3 |
2 |
C4 |
| ILMN_17569 |
OGG1 |
8-oxoguanine DNA glycosylase, transcript variant 1b |
-2.34 |
0.66 |
-0.30 |
-0.02 |
17 |
17 |
1 |
C4 |
| ILMN_10755 |
CKB |
creatine kinase, brain |
-2.29 |
0.88 |
-0.76 |
0.39 |
14 |
9 |
2 |
C4 |
| ILMN_13759 |
GPR30 |
G protein-coupled receptor 30, transcript variant 1 |
-2.28 |
0.73 |
-0.51 |
0.08 |
19 |
12 |
2 |
C4 |
| ILMN_20448 |
CPA2 |
carboxypeptidase A2 (pancreatic) |
-2.21 |
0.65 |
-0.38 |
-0.09 |
47 |
26 |
4 |
nc |
| ILMN_20479 |
SIGLEC11 |
sialic acid binding Ig-like lectin 11 |
-2.20 |
0.91 |
-0.38 |
0.04 |
13 |
8 |
1 |
C4 |
| ILMN_23656 |
SH3GL2 |
SH3-domain GRB2-like 2 |
-2.18 |
0.78 |
-0.26 |
-0.07 |
17 |
12 |
1 |
C4 |
| ILMN_28182 |
FLJ35258 |
hypothetical protein 284297 |
-2.18 |
0.76 |
-0.38 |
0.47 |
16 |
7 |
1 |
C4 |
| ILMN_28694 |
CDH2 |
cadherin 2, type 1, N-cadherin (neuronal) |
-2.17 |
0.86 |
-0.20 |
-0.06 |
16 |
7 |
1 |
C4 |
| ILMN_5239 |
FNDC5 |
fibronectin type III domain containing 5 |
-2.13 |
0.88 |
-0.37 |
0.29 |
12 |
4 |
1 |
C4 |
| ILMN_19137 |
MFSD4 |
major facilitator superfamily domain containing 4 |
-2.09 |
0.86 |
-0.49 |
0.16 |
13 |
9 |
1 |
C4 |
| ILMN_6662 |
TRIM50 |
tripartite motif-containing 50 |
-2.05 |
0.84 |
-0.24 |
-0.07 |
16 |
13 |
1 |
C4 |
| ILMN_16766 |
ZNF533 |
zinc finger protein 533 |
-2.04 |
0.85 |
-0.37 |
0.07 |
12 |
7 |
1 |
C4 |
| ILMN_27352 |
CLIC6 |
chloride intracellular channel 6 |
-2.02 |
0.64 |
-0.40 |
-0.05 |
20 |
11 |
2 |
nc |
| ILMN_4712 |
SERPINA5 |
serpin peptidase inhibitor, clade A, member 5 |
-2.02 |
0.88 |
-0.40 |
-0.09 |
14 |
1 |
2 |
C4 |
| ILMN_15602 |
CLCNKA |
chloride channel Ka |
-2.01 |
0.88 |
-0.28 |
-0.06 |
14 |
8 |
1 |
C4 |
| ILMN_19114 | DNER | delta-notch-like EGF repeat-containing transmembrane | -2.01 | 0.86 | -0.54 | 0.22 | 12 | 5 | 2 | C4 |
The goodness of fits were also reported by R2;
aRegression coefficient. Linear regression was performed along the three patient groups (Hp-, Hp + and Atr).
bCorpus vs. antrum gene expression fold changes of the individual patient groups.
cThe result from clustering analysis; nc = not included in clustering analysis.