Table 1.
Clinical characteristics of the patients at CRRT start
| Variable | Protocol A (n = 20) | Protocol B (n = 20) | P value |
|---|---|---|---|
| Female gender |
7/20 (35%) |
4/20 (20%) |
0.480 |
| Age, years |
72 (69–77) |
70 (59–73) |
0.073 |
| Body weight, kg |
72 (67–79) |
70 (66–80) |
0.715 |
| Oliguric AKI § |
90% |
75% |
0.407 |
| Mean arterial pressure, mmHg |
70 (70–80) |
70 (62–80) |
0.399 |
| Use of vasopressors or inotropes |
75% |
85% |
0.695 |
| Mechanical ventilation |
85% |
90% |
0.633 |
| Artificial nutrition |
95% |
100% |
0.311 |
| APACHE II score |
32 (29–35) |
32 (27–35) |
0.307 |
| SOFA score |
15 (12–16) |
13 (9–14) |
0.056 |
| SOFA cardio-vascular score |
3 (2–3) |
3 (2–3) |
0.130 |
| Serum creatinine, mg/dl |
2.10 (1.75–3.00) |
2.25 (1.75–2.85) |
0.469 |
| Blood urea nitrogen, mg/dl |
40.5 (26.9–62.0) |
40.5 (29.0–55.2) |
0.978 |
| Hemoglobin, g/dl |
10.9 (9.9–11.2) |
10.0 (8.8–10.9) |
0.084 |
| Hematocrit,% |
32.1 (31.2–33.4) |
31.6 (27.5–34.5) |
0.419 |
| White blood cells, ×103/μl |
11.0 (8.2–15.9) |
12.4 (11.0–16.5) |
0.664 |
| Platelet count, ×103/μl |
93 (76–177) |
161 (98–254) |
0.043 |
| Antithrombin III activity,% |
70 (63–78) |
61 (49–78) |
0.250 |
| APTT Ratio |
1.4 (1.3–1.9) |
1.6 (1.4–2) |
0.358 |
| Sodium, mmol/l |
139 (134–140) |
139 (137–143) |
0.110 |
| Potassium, mmol/l |
4.3 (4.0–4.8) |
4.2 (4.1–4.8) |
0.762 |
| Total Calcium, mmol/l |
2.16 (1.95–2.30) |
2.03 (1.93–2.19) |
0.166 |
| Phosphorus, mmol/l |
1.40 (1.07–1.58) |
1.38 (1.16–1.70) |
0.897 |
| Magnesium, mmol/l |
0.85 (0.75–0.93) |
0.78 (0.74–0.97) |
0.572 |
| pH, units |
7.38 (7.35–7.41) |
7.40 (7.38–7.43) |
0.324 |
| Bicarbonate, mmol/l |
21.8 (21.0–22.6) |
22.2 (21.0–24.2) |
0.535 |
| Base Excess |
-3.5 (-4.0 to -2.0) |
-1.0 (-4.0 to 1.0) |
0.316 |
| pCO2, mmHg |
38 (36–42) |
37 (33–40) |
0.992 |
| Lactate, mmol/l |
1.4 (1.0–3.0) |
1.4 (1.2–2.4) |
0.879 |
| Bilirubin, mg/dl |
0.89 (0.62–1.45) |
0.73 (0.46–1.37) |
0.376 |
| Aspartate aminotransferase, IU/l |
89 (29–608) |
97 (49–376) |
0.800 |
| Alanine aminotransferase, IU/l |
37 (12–325) |
26 (18–75) |
0.970 |
| Albumin, g/dl |
2.6 (2.4–2.8) |
2.45 (2.2–2.9) |
0.820 |
|
Heart surgery: |
|
|
Overall |
| Coronary artery bypass grafting |
25% |
35% |
30% |
| Coronary artery bypass grafting + valvular surgery |
40% |
15% |
27.5% |
| Valvular surgery |
25% |
20% |
22.5% |
| Ascending aorta replacement | 10% | 30% | 20% |
Data are expressed as median (IQR) or percentage. § According to AKIN criteria (Crit Care 2007; 11:R31).