Table 2.
Initial RCA-CRRT settings
| RCA-CRRT settings | Protocol A | Protocol B | P-value |
|---|---|---|---|
| Prescribed dialysis dose§, ml/kg/h |
28.25 (26.69–29.66) |
26.67 (25.69–28.88) |
0.333 |
| Blood flow rate, ml/min |
130 (130–140) |
140 (140–140) |
0.083 |
| Pre-dilution citrate solution flow rate, l/h |
1.56 (1.50–1.68) |
1.00 (1.00–1.00) |
<0.001 |
| Pre-dilution,% |
16.67 (16.58–16.67) |
10.64 (10.64–10.64) |
<0.001 |
| Post-dilution replacement fluid flow rate, l/h |
0.80 (0.80–0.95) |
0.60 (0.55–0.80) |
<0.001 |
| Dialysate flow rate, l/h |
N/A |
0.50 (0.50–0.50) |
- |
| Filtration Fraction,% |
38.4 (34.5–40.3) |
27.0 (25.7–28.8) |
<0.001 |
| 10% Calcium chloride infusion rate, mmol/h |
2.00 (1.60–2.10) |
1.90 (1.36–2.28) |
0.344 |
| Citrate infusion rate, mmol/h |
18.70 (18.00–20.15) |
18.00 (18.00–18.00) |
0.051 |
| Estimated citrate load, mmol/h |
12.34 (11.74–13.92) |
12.35 (12.05–12.65) |
0.471 |
| Estimated citrate dose, mmol/l | 2.84 (2.74–2.91) | 2.83 (2.76–2.95) | 0.618 |
Data are expressed as median (IQR). § Corrected for pre-dilution.