Table 4.
Laboratory variables and supplementation needs during RCA-CRRT
| Variable | Protocol A (n = 20) | Protocol B (n = 20) | P value |
|---|---|---|---|
| Systemic Ca2+, mmol/l |
1.16 (1.10–1.23) |
1.16 (1.11–1.21) |
0.995 |
| Total Calcium, mmol/l |
2.33 (2.20–2.50) |
2.33 (2.21–2.45) |
0.474 |
| Calcium Ratio |
1.95 (1.84–2.09) |
1.98 (1.89–2.09) |
0.296 |
| Circuit Ca2+, mmol/l |
0.37 (0.32–0.40) |
0.42 (0.36–0.47) |
<0.001 |
| Sodium, mmol/l |
134 (133–136) |
134 (132–135) |
0.213 |
| Potassium, mmol/l |
4.2 (4.0–4.3) |
4.2 (4.0–4.4) |
0.159 |
| Phosphate, mmol/l |
0.70 (0.50–1.00) |
1.20 (0.97–1.45) |
<0.001 |
| Magnesium, mmol/l |
0.78 (0.58–0.95) |
0.79 (0.73–0.84) |
<0.001 |
| pH, units |
7.40 (7.36–7.44) |
7.43 (7.40–7.46) |
<0.001 |
| Bicarbonate, mmol/l |
22.1 (20.9–23.5) |
25.3 (23.8–26.6) |
<0.001 |
| Base Excess |
-3.1 (-4.6 to -1.1) |
0.9 (-0.8 to 2.4) |
<0.001 |
| pCO2, mmHg |
35 (32–41) |
38 (35–40) |
0.527 |
| Apparent strong ion difference (AppSID), mEq/l |
37.6 (36.1–39.4) |
39.1 (37.9–40.2) |
<0.001 |
| Effective strong ion difference (EffSID), mEq/l |
32.0 (30.6–33.1) |
34.3 (32.8–35.9) |
<0.001 |
| Strong ion gap (SIG), mEq/l |
5.8 (3.5–7.7) |
4.5 (3.1–6.9) |
0.585 |
| Lactate, mmol/l |
1.2 (0.9–1.6) |
1.1 (0.8–1.4) |
<0.001 |
| Platelet count, ×103/μl |
90 (53–156) |
187 (121–261) |
<0.001 |
| Antithrombin III activity,% |
72 (62–81) |
75 (63–89) |
0.078 |
| aPTT Ratio |
1.4 (1.3–1.6) |
1.4 (1.2–1.7) |
0.575 |
|
Supplementation needs |
|
|
|
| CaCl2 infusion, mmol/h |
2.18 (1.90–2.45) |
2.24 (1.97–2.58) |
0.800 |
| KCl infusion, mmol/h |
5 (3–7) |
2 (0–4) |
<0.001 |
| Magnesium Sulphate, g/day |
3 (2–3) |
3 (3–3) |
<0.001 |
| Need for bicarbonate infusion, n (%) |
18/20 (90%) |
0/20 (0%) |
<0.001 |
| Infusion rate, mmol/h |
6 ± 6.4 |
No supplementation |
|
| Need for phosphate supplementation, n (%) |
20/20 (100%) |
6/20 (30%) |
<0.001 |
| g of phosphorus/day | 3.39 ± 2.45 | 0.52 ± 1.53 |
Data are expressed as median (IQR) or mean ± SD or percentage.