Figure 3.

Abnormal bone remodeling and calcium metabolism in patients with osteoporosis. Antiresorptive agents improve abnormal bone remodeling in osteoporotic patients. In order for these agents to enhance bone mineralization and improve bone strength, reduction in intestinal Ca absorption observed in the elderly subjects needs to be corrected. Most of the global fracture prevention studies use native vitamin D and calcium as supplements. However, eldecalcitol is available in Japan, which not only improves negative Ca balance by enhancing intestinal Ca absorption but also improves negative bone remodeling balance, and reduces vertebral fracture incidence. Eldecalcitol may reduce falls, like other active vitamin D compounds that are reported to have a preventive effect on falls. This may also contribute to the reduction in fractures.