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. Author manuscript; available in PMC: 2014 May 9.
Published in final edited form as: FEMS Immunol Med Microbiol. 2012 May 25;65(3):467–480. doi: 10.1111/j.1574-695X.2012.00978.x

Fig. 4.

Fig. 4

Pretreatment with probiotic Lactobacillus acidophilus (La), prebiotic inulin, or synbiotics alters cytokine responses in the MLN of mice. Cells from the MLN were isolated from mice 2 weeks post-Citrobacter rodentium infection of each treatment and exposed ex vivo to C rodentium antigen (C-Ag) in culture. Culture supernatants were collected after 72 h and assayed for cytokine production. (a) Synbiotic group showed a significant impact on the response of IL-10. (b) Pretreatment with synbiotic (probiotic La + prebiotic inulin) significantly reduced IFN-γ levels. *P < 0.05 when compared to other treatment groups, based on one-way anova (Tukey's multiple comparison test). The results were displayed as means ± SEM and were representative of three independent experiments with N = 7–10 pups per treatment.