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. 2014 Apr 1;28(7):723–734. doi: 10.1101/gad.236869.113

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© 2014 Saldaña-Meyer et al.; Published by Cold Spring Harbor Laboratory Press

This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genesdev.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

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Figure 4. — Deletion of the RBR within CTCF disturbs the DNA damage response. Cell lines containing HA-CTCF_wt or HA-CTCF_Δ576–614 were induced with doxycycline for 56 h and then treated for an additional 16 h with doxycycline with or without the DNA-damaging drug MMS, as indicated. (A) RT-qPCR for the transcripts indicated, shown as fold induction and normalized to GAPDH levels. Bars indicate the mean of three biological replicates + SEM. (*) P < 0.05 by Mann-Whitney U-test. (B) Immunoblot of p53 and Wrap53, with β-actin as loading control.