FIG. 1.

Serine protease inhibitor kunitz-type 2 (SPINT2) and hepatocyte growth factor (HGF) expression in normal and myelodysplastic mesenchymal stromal cells (MSCs). (A) Age-adjusted SPINT2 mRNA expression was significantly lower in MSCs from myelodysplastic syndrome (MDS) patients compared with healthy donors. (B) Age-adjusted HGF mRNA expression was significantly higher in MSCs from MDS patients as compared with healthy donors. (C) Horizontal lines represent median values; Mann–Whitney and analysis of variance tests were used as nonparametric test. (C) Correlation analysis between SPINT2 expression and HGF expression in MSCs. P and r values are indicated; Spearman correlation test.