Table 1.
Characteristics of non-Hispanic white BRCA1 and BRCA2 mutation carriers, by case-control status
| BRCA1 mutation carriers | BRCA2 mutation carriers | |||||||
|---|---|---|---|---|---|---|---|---|
|
| ||||||||
| Cases (n=167) | Controls (n=287) | Cases (n=104) | Controls (n=169) | |||||
| N | % | N | % | N | % | N | % | |
| Reference age (years) | ||||||||
| <30 | 18 | 11 | 77 | 27 | 8 | 8 | 34 | 20 |
| 30–39 | 73 | 44 | 104 | 36 | 51 | 49 | 57 | 34 |
| 40–49 | 76 | 45 | 106 | 37 | 45 | 43 | 78 | 46 |
| Study site | ||||||||
| Australia | 75 | 45 | 117 | 41 | 50 | 48 | 84 | 50 |
| Canada | 39 | 23 | 11 | 4 | 27 | 26 | 12 | 7 |
| USA | 53 | 32 | 159 | 55 | 27 | 26 | 73 | 43 |
| Ascertainment | ||||||||
| Clinic-based | 99 | 59 | 271 | 94 | 59 | 57 | 148 | 88 |
| Population-based | 68 | 41 | 16 | 6 | 45 | 43 | 21 | 12 |
| Education | ||||||||
| Less than college or university | 45 | 27 | 51 | 18 | 18 | 17 | 39 | 23 |
| Some college or university | 67 | 40 | 124 | 43 | 52 | 50 | 66 | 39 |
| College or university degree | 54 | 33 | 112 | 39 | 31 | 30 | 64 | 38 |
| Unknown | 0 | 0 | 0 | 0 | 3 | 3 | 0 | 0 |
| Family history of breast or ovarian cancer a | ||||||||
| Yes | 102 | 61 | 218 | 76 | 56 | 54 | 119 | 70 |
| No | 65 | 39 | 69 | 24 | 48 | 46 | 50 | 30 |
| Full-term pregnancies | ||||||||
| 0 | 45 | 27 | 97 | 34 | 22 | 21 | 37 | 22 |
| 1–2 | 85 | 51 | 111 | 39 | 48 | 46 | 78 | 46 |
| ≥3 | 37 | 22 | 78 | 27 | 34 | 33 | 54 | 32 |
in first-degree relatives