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. 2010 Oct 21;2(2):111–122. doi: 10.1111/j.2040-1124.2010.00071.x

Figure 2.

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 Expressions of human aldose reductase (hAR) and murine aldose reductase (mAR) in experimental mice. hAR was expressed in both the cortex and medulla in transgenic mice expressing hAR (Tg), but not in control wild‐type mice (Wt). In contrast, mAR was expressed strongly in the medulla and less so in the cortex. Diabetic condition (D) enhanced hAR expressions in both the cortex and medulla, whereas the effects of diabetes (D) on the mAR expression were uncertain. Tg + D, diabetic transgenic mice; Tg + D + ARI, aldose reductase inhibitor‐treated diabetic Tg; Wt + D, diabetic control mice; Wt + D + ARI, diabetic control mice treated with aldose reductase inhibitor.