Table 2.  Carbohydrate levels in the kidney cortex of experimental mice.

		Glucose (g) (nmol/mg wet weight)	Sorbitol (nmol/mg wet weight)	Fructose (nmol/mg wet weight)
Non‐diabetic Wt	n = 5	2.29 ± 0.14	0.036 ± 0.006	0.031 ± 0.001
Diabetic Wt	n = 5	19.82 ± 3.95†	0.109 ± 0.021†	0.098 ± 0.031†
Diabetic Wt + ARI	n = 5	20.11 ± 2.94†	0.108 ± 0.005†	0.160 ± 0.019†‡
Tg	n = 5	2.29 ± 0.14	0.056 ± 0.011†	0.034 ± 0.002
Diabetic Tg	n = 5	20.86 ± 1.86§	0.207 ± 0.057§¶	0.153 ± 0.022§¶
Diabetic Tg + ARI	n = 5	20.90 ± 2.52§	0.080 ± 0.015*	0.145 ± 0.005§

Values are mean ± SD. †P < 0.01 vs non‐diabetic Wt, ‡P < 0.01 vs diabetic Wt, §P < 0.01 vs non‐diabetic Tg, ¶P < 0.01 vs diabetic Wt, *P < 0.01 vs diabetic Tg.

ARI, aldose reductase inhibitor; Tg, transgenic mice expressing human aldose reductase; Wt, control wild‐type mice.