Table 3.  Morphometric data of the renal glomeruli in experimental mice.

		Total glomerular surface area (mm2)	Glomerular tuft surface area (mm2)	Mesangial thickness (mm2)	Basement membrane (nm)
Non‐diabetic Wt	n = 5	3406 ± 321	2625 ± 242	474 ± 43	218 ± 13
Diabetic Wt	n = 5	4921 ± 704†	3594 ± 488†	737 ± 152†	218 ± 8
Diabetic Wt + ARI	n = 5	4765 ± 374†	3480 ± 447†	607 ± 130	205 ± 18
Non‐diabetic Tg	n = 5	3307 ± 321	2477 ± 270	484 ± 46	249 ± 8‡
Diabetic Tg	n = 5	5600 ± 836§	3980 ± 515§	803 ± 119§	221 ± 25
Diabetic Tg + ARI	n = 5	5043 ± 368§	3523 ± 366§	619 ± 83¶*	216 ± 12§

Values are mean ± SD. †P < 0.01 vs non‐diabetic Wt, ‡P < 0.01 vs non‐diabetic Wt and diabetic Tg + ARI, §P < 0.01 vs non‐diabetic Tg, ¶P < 0.02 vs non‐diabetic Tg, *P < 0.05 vs diabetic Tg.

ARI, aldose reductase inhibitor; Tg, transgenic mice expressing human aldose reductase; Wt; control wild‐type mice.