Table 3.
Summary of parasite isolate genotypes containing resistance-associated alleles in the in vivo drug efficacy study in the North Atlantic Autonomous Region, Nicaragua 2005–2006*
| Isolate | Location | Allele | ||
|---|---|---|---|---|
| pfcrt | pdhfr | pdhps | ||
| Wild type | CVMNK | CNCSI | SAKAA | |
| Isolate 1 | Rosita | CVIET | CNCSI | SAKAA |
| Isolate 2 | Siuna | CVIET | CIRNI | SGKAA |
| Isolate 3 | Siuna | CVMNK | CNCNI | SAKAA |
*
Alleles described by amino acids in key positions for each gene as in Table 2. Amino acid changes indicating polymorphism are underlined. pfcrt = Plasmodium falciparum chloroquine resistance transporter; pdhfr = P. falciparum dihydrofolate reductase; pdhps = P. falciparum dihydropteroate synthase.