Figure 3.
Effect of Ang-2 overexpression on CNE2 tumor growth under different VEGF level. Six groups of engineered CNE2 cells with different Ang-2 and VEGF levels were subcutaneously inoculated into six groups of nude mice (A-F) respectively. Tumor volumes were calculated dynamically (a), and tumors were weighed (b) when the mice were sacrificed on the 27th day after inoculation. There was no significant difference on tumor development among A,B,C. (P > 0.05), while E and F exhibited greatly suppressed tumor growth compared with A,B,C,D (**P < 0.01, *P < 0.05 vs A,B,C,D, ## P < 0.01 vs F). E had higher inhibitory effects than F on tumor growth.