Extended Data Figure 1. Castration or ovariectomy modestly increased the numbers of B cells in the bone marrow without affecting the numbers of HSCs or MPPs.

a, Castration (Cast) or ovariectomy (Ovx) did not significantly affect the numbers of HSCs or MPPs in the bone marrow (femurs and tibias). b, Castration or ovariectomy significantly increased the numbers of B220⁺ B-cells in the bone marrow but did not affect the numbers of Mac-1⁺/Gr-1⁺ myeloid cells, CD3⁺ T-cells, or Ter119⁺ erythroid cells in the bone marrow or spleen. 3 sham and 4 gonadectomized mice used in 3 independent experiments. All data represent mean±standard deviation; *, p<0.05 by Student’s t-test.