Table 2. Insulin pharmacokinetic parameters and metrics.
| 32G × 4 | 32G × 6 | 31G × 8 | |
|---|---|---|---|
| Identified parameters | |||
| k4 (per min) | 0.0275 ± 0.0105 | 0.0252 ± 0.007 | 0.0236 ± 0.0069 |
| k5 (per min) | 0.0378 ± 0.0164 | 0.037 ± 0.0135 | 0.0365 ± 0.0221 |
| k6 (per min) | 0.2737 ± 0.0334 | 0.2567 ± 0.0587 | 0.2559 ± 0.0456 |
| VIP (L) | 4.35 ± 0.37 | 4.46 ± 0.43 | 4.39 ± 0.33 |
| F | 0.39 ± 0.11 | 0.34 ± 0.11 | 0.37 ± 0.10 |
| PK metrics | |||
| Tmax (min) | 39.39 ± 9.26 | 39.76 ± 6.09 | 43.01 ± 8.03 |
| Cmax (μU/mL) | 16.99 ± 4.17 | 16.95 ± 3.22 | 17.19 ± 4.08 |
| AUC0‐∞ (min μU/mL) | 1420 ± 255 | 1506 ± 259 | 1539 ± 279 |
| Cmax/dose (μU/mL) | 9.65 ± 2.79 | 9.69 ± 2.41 | 9.70 ± 2.45 |
| AUC0‐∞/dose (min μU/mL) | 795 ± 104 | 845 ± 115 | 860 ± 101 |
Values are means ± standard deviation. The identified exogenous parameters were determined by fitting the overall model to the total measured insulin by the non‐linear least squares method. The parameters for C‐peptide and insulin secretion compartments were calculated using mathematical relationships as a function of participant characteristics. Although the two‐rate constants k4 and k5 are identifiable, they are interchangeable. In this table, k4 is reported as the smaller of the two and k5 is reported as the larger of the two. The maximum insulin concentration (Tmax), maximum concentration (Cmax) and area under the curve for 0 to infinity min (AUC0–∞) are derived from the simulated exogenous plasma insulin curve resulting from the identified parameters when insulin secretion was set to 0. PK, pharmacokinetic.