Table 3. Bioequivalence analysis of 32‐G × 4 mm vs 32‐G × 6 mm and 31‐G × 8 mm needles for insulin pharmacokinetics.
| Ratioa | 90% CI | Lower/upper limitsb | |
|---|---|---|---|
| Tmax (min) | |||
| 32G × 4 vs 32G × 6 | −0.3667 | −5.8597, 5.1264 | −7.9517, 7.9517 |
| 32G × 4 vs 31G × 8 | −3.6167 | −9.6907, 2.4574 | −8.6017, 8.6017 |
| Cmax (μU/mL) | |||
| 32G × 4 vs 32G × 6 | −0.0109 | −0.1713, 0.1496 | −0.2230, 0.2231 |
| 32G × 4 vs 31G × 8 | −0.0164 | −0.1893, 0.1565 | −0.2230, 0.2231 |
| AUC0–∞ (min μU/mL) | |||
| 32G × 4 vs 32G × 6 | −0.0608 | −0.1827, 0.0611 | −0.2230, 0.2231 |
| 32G × 4 vs 31G × 8 | −0.0810 | −0.2076, 0.0457 | −0.2230, 0.2231 |
CI, confidence interval; Tmax, time to the maximum concentration; Cmax, maximum concentration; AUC0–∞, area under the curve from 0 to infinity min.
a
Ratio of the mean values.
b
±20% for time to the maximum concentration (Tmax), log (0.80), log (1.25) for maximum concentration (Cmax) and area under the curve from 0 to infinity min (AUC0–∞).