Table 1.
Differently expressed total proteins in HIV-infected-monocytes co-cultured with HBMEC
| Protein | HIV vs. control fold change | P-value | HIV vs. TAK fold change | P-value | Location |
|---|---|---|---|---|---|
| Src |
3.05 |
5.09E-10 |
0.67 |
3.34E-05 |
Cytoplasm |
| MKK3/MAP2K3 |
2.78 |
3.62E-09 |
0.41 |
1.16E-11 |
Cytoplasm |
| PKC alpha |
2.56 |
7.34E-08 |
0.57 |
6.81E-06 |
Cytoplasm |
| p130Cas |
2.51 |
2.06E-08 |
0.54 |
1.16E-11 |
Plasma membrane |
| MKK7/MAP2K7 |
2.41 |
5.47E-09 |
0.45 |
1.16E-11 |
Cytoplasm |
| CaMK2-beta/gamma/delta |
2.40 |
1.61E-09 |
0.69 |
3.61E-04 |
Nucleus |
| Ezrin |
2.22 |
4.15E-10 |
0.50 |
1.16E-11 |
Plasma membrane |
| PLC beta3 |
2.17 |
3.62E-09 |
0.48 |
1.09E-06 |
Cytoplasm |
| c-Raf |
2.07 |
1.99E-11 |
0.57 |
1.29E-11 |
Cytoplasm |
| PLC-beta |
2.04 |
7.50E-07 |
0.53 |
2.09E-10 |
Cytoplasm |
| WAVE1 |
2.02 |
3.19E-06 |
1.17 |
1.61E-03 |
Nucleus |
| LIMK1 |
1.99 |
1.99E-11 |
0.46 |
3.08E-11 |
Cytoplasm |
| Myosin regulatory light chain 2 | 1.99 | 5.47E-09 | 0.63 | 7.03E-11 | Cytoplasm |
HBMEC: human brain microvascular endothelial cells; HIV: human immunodeficiency virus-1.
Unadjusted P values, P values adjusted for multiple comparisons using Tukey post-hoc test, and P values adjusted for false discovery rate using the Benjamini & Hochberg method were all significant. Table show P values adjusted using the Benjamini & Hochberg method.
Src: v-src sarcoma viral oncogene homolog; MKK3/MAP2K3: mitogen-activated protein kinase kinase3; PKC: protein kinase C; p130Cas: breast cancer anti-estrogen resistance 1; MKK7/MAP2K7: mitogen-activated protein kinase kinase 7; CAMK2: calcium/calmodulin-dependent protein kinase-2; PLC: phospholipase C; c-raf: v-raf-1 murine leukemia viral oncogene homolog 1; WAVE1: WAS protein family 1; LIMK1: LIM domain kinase 1.