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. 2014 Feb 6;12:15. doi: 10.1186/1477-7827-12-15

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Copyright © 2014 Yuan et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver ( http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Testosterone secretion was influenced by the expression of SOCS3 and pSTAT3 level. (A) The expression of SOCS3 and STAT3/pSTAT3 after stimulation of 100 nM leptin was detected by western blotting. (B) The expression of SOCS3 after stimulation of 100 nM leptin could regulate the secretion of testosterone. (C) It was confirmed that AG490 (20 μM) could block STAT3 phosphorylation. (D) The induced role of low concentrations of leptin and inhibited role of high concentrations of leptin both dropped compared with the DMSO-alone group. The means were compared using a one-way analysis of variance followed by Student-Newman-Keuls test to conduct multiple comparisons. *, p < 0.05; NSD, non-significant difference. The photograph is representative of three independent experiments. Each column and bar represents the mean ± SD of three independent experiments.