Table 2.
Plasma AGE-levels in individuals with and without T1DM
| |
|
Model 1 |
Model 2 |
||||
|---|---|---|---|---|---|---|---|
| Mean | 95%-CI | p-value | Mean | 95%-CI | p-value | ||
|
Pentosidine* (nmol/mmol LYS) |
control |
0.51 |
0.48 – 0.53 |
|
0.51 |
0.48 – 0.54 |
|
|
T1DM |
0.69 |
0.65 – 0.73 |
<0.001 |
0.69 |
0.65 – 0.73 |
<0.001 |
|
|
CML (nmol/mmol LYS) |
control |
92.3 |
89.6 – 94.9 |
|
92.6 |
90.1 – 95.1 |
|
|
T1DM |
104.8 |
102.1 – 107.5 |
<0.001 |
104.5 |
102.0 – 107.0 |
<0.001 |
|
|
CEL (nmol/mmol LYS) |
control |
14.5 |
14.0 – 15.0 |
|
14.6 |
14.1 – 15.2 |
|
|
T1DM |
15.0 |
14.5 – 15.5 |
0.212 |
14.9 |
14.4 – 15.4 |
0.489 |
|
| THP* (U/mL) |
control |
112.7 |
106.2 – 119.7 |
|
112.7 |
105.7 – 119.9 |
|
| T1DM | 125.6 | 118.0 – 133.4 | 0.015 | 125.6 | 117.8 – 134.0 | 0.025 | |
Data are presented as adjusted means or geometric means* of AGEs in individuals with and without T1DM, by use of a complete case analysis.
n = 169 for individuals without and n = 165 for individuals with T1DM.
Model 1 was adjusted for age and sex. Model 2 was adjusted for age, sex, SBP, DBP, BMI, WHR, pack-years of smoking, LDL, HDL, triglycerides and eGFR.
CML, N(epsilon)-(carboxymethyl)lysine; CEL, N(epsilon)-(carboxyethyl)lysine; THP, tetrahydropyrimidine.