Table 3.
Plasma AGE-levels in individuals with T1DM and a moderate to high compared with a low CAC score
| |
|
Model 1 |
Model 2 |
||||
|---|---|---|---|---|---|---|---|
| Mean | 95%-CI | p-value | Mean | 95%-CI | p-value | ||
|
Pentosidine* (nmol/mmol LYS) |
CAC = 0-10 |
0.67 |
0.63 – 0.72 |
|
0.67 |
0.63 – 0.71 |
|
|
CAC > 10 |
0.80 |
0.69 – 0.92 |
0.034 |
0.81 |
0.70 – 0.93 |
0.028 |
|
|
CML (nmol/mmol LYS) |
CAC = 0-10 |
105.0 |
101.7 – 108.2 |
|
104.5 |
101.5 – 107.5 |
|
|
CAC > 10 |
102.9 |
95.8 – 110.0 |
0.608 |
105.0 |
98.3 – 111.8 |
0.883 |
|
|
CEL (nmol/mmol LYS) |
CAC = 0-10 |
14.9 |
14.2 – 15.5 |
|
14.9 |
14.3 – 15.5 |
|
|
CAC > 10 |
15.9 |
14.6 – 17.3 |
0.166 |
15.9 |
14.6 – 17.3 |
0.163 |
|
| THP* (U/mL) |
CAC = 0-10 |
122.2 |
113.5 – 131.8 |
|
121.6 |
112.7 – 131.2 |
|
| CAC > 10 | 140.6 | 119.4 – 165.6 | 0.131 | 143.9 | 121.3 – 170.6 | 0.086 | |
Data are presented as adjusted means or geometric means* of AGEs in individuals with a CAC score of 0–10 compared to >10 in individuals with T1DM, by use of a complete case analysis.
n = 135 for individuals with a calcification score of 0–10; n = 30 for individuals with a calcification score of >10.
Model 1 was adjusted for age and sex. Model 2 was adjusted for age, sex, SBP, DBP, BMI, WHR, pack-years of smoking, LDL, HDL, triglycerides and eGFR. CML, N(epsilon)-(carboxymethyl)lysine; CEL, N(epsilon)-(carboxyethyl)lysine; THP, tetrahydropyrimidine.