. 2014 May 5;7:111–116. doi: 10.2147/IDR.S60906

Table 1.

Comparison of mutation frequencies of single nucleotide polymorphisms in the pfdhfr, pfmdr1, pfcrt, and pfATP6 genes associated with drug-resistance between samples collected from Plasmodium falciparum-infected patients working/living in mining areas and villagers (nonminers)

Gene and positions	% mutation in miners	% mutation in villagers
pfdhfr
A16V	0% (n=27)	0% (n=30)^a
N51I	100% (n=27)	100% (n=30)^a
C59R	0% (n=26)	0% (n=30)^a
S108N	100% (n=28)	100% (n=30)^a
I164L	0% (n=27)	0% (n=30)^a
pfmdr1
N86Y	0% (n=27)	0% (n=40)^b
Y184F	100% (n=27)	100% (n=40)^b
S1034C	96% (n=26)	95% (n=40)^b
N1042D	100% (n=28)	100% (n=40)^b
D1246Y	100% (n=28)	100% (n=40)^b
pfcrt
K76T	100% (n=28)	100% (n=40)^b
pfATP6
L263E	0% (n=28)	0% (n=24)^c
A623E	0% (n=27)	0% (n=24)^c
S769N	0% (n=27)	0% (n=24)^c

Notes:

Isolates from 2002 (unpublished data);

isolates from 2005–2006 (data from Adhin et al¹⁹);

isolates from 2002–2006 (data from Adhin et al¹³). The letters are abbreviations for different amino acids in the pfdhfr, pfmdr1, and pfcrt gene products. n represents the number of successfully amplified samples for the respective position in each study.