Table 5.

Different gene significant downregulated GO

GO item	Fold enrichment	P value
Calcium-dependent cell-cell adhesion	9.49	3.90 × 10-2
Response to acid	9.09	4.22 × 10-2
Embryonic skeletal system development	5.67	4.04 × 10-3
Response to vitamin	5.51	1.26 × 10-2
Regulation of cell shape	5.39	3.75 × 10-2
Regulation of Rho protein signal transduction	5.14	2.36 × 10-3
Pigmentation	4.93	4.68 × 10-2
Cartilage development	4.91	1.85 × 10-2
Skeletal system morphogenesis	3.90	1.88 × 10-2
Regulation of cell morphogenesis	3.89	9.22 × 10-3
Translational elongation	3.60	4.97 × 10-2
Muscle tissue development	3.49	2.85 × 10-2
Homophilic cell adhesion	3.33	3.40 × 10-2
Regulation of neuron differentiation	3.28	3.59 × 10-2
Embryonic organ morphogenesis	3.28	3.59 × 10-2
Regulation of cell development	3.19	7.23 × 10-3
Regulation of Ras protein signal transduction	3.12	8.25 × 10-3
Muscle organ development	3.10	8.54 × 10-3
Regulation of neurogenesis	3.07	2.66 × 10-2
Response to drug	3.03	9.75 × 10-3
Embryonic organ development	2.96	3.09 × 10-2
Regulation of small GTPase mediated signal transduction	2.89	7.88 × 10-3
Skeletal system development	2.74	4.38 × 10-3
Heart development	2.71	2.85 × 10-2
Regulation of nervous system development	2.65	4.85 × 10-2
Cell-cell adhesion	2.64	1.37 × 10-2
Negative regulation of cell proliferation	2.62	4.07 × 10-3
Cell adhesion	2.60	2.99 × 10-5
Biological adhesion	2.59	3.06 × 10-5
Actin cytoskeleton organization	2.57	3.59 × 10-2
Actin filament-based process	2.41	4.79 × 10-2
Chordate embryonic development	2.20	3.87 × 10-2
Embryonic development ending in birth or egg hatching	2.18	4.03 × 10-2
Cytoskeleton organization	2.17	1.68 × 10-2
Regulation of cell proliferation	2.03	2.54 × 10-3
Response to organic substance	1.71	3.85 × 10-2