Table 2.
Correlations of operative and metastatic status/management with clinicopathologic features of renal cell carcinoma extending into venous system
| Variables |
Operative status of RCC extending to the venous system and metastatic status/management |
Statistical significance (chi-square test or Mann–Whitney U test) | ||||
|---|---|---|---|---|---|---|
|
Radical nephrectomy and complete resection of thrombus |
Radical nephrectomy and incomplete resection of thrombus regardless of metastatic status |
Abandoned operation |
||||
| Without metastasis | Existing metastasis and undergoing cytoreductive operation | With unresected metastases | ||||
| |
Surgical category 1 |
Surgical category 2 |
Surgical category 3 |
Surgical category 4 |
Surgical category 5 |
|
|
n |
196 |
11 |
66 |
8 |
11 |
|
|
Age (years) | ||||||
| Mean ± SD |
63.0 ± 11.0 |
57.5 ± 9.1 |
61.7 ± 9.8 |
54.3 ± 5.8 |
66.8 ± 13.8 |
p < 0.05; surgical category 4 vs. surgical category 1, 3, 5 |
|
Performance status (n) | ||||||
| 0 |
143 |
7 |
43 |
4 |
0 |
p < 0.05: surgical category 1, 2, 3 vs. surgical category 5 surgical category 1 vs. surgical category 4 |
| 1 |
22 |
2 |
10 |
1 |
4 |
|
| 2 |
6 |
1 |
5 |
0 |
2 |
|
| 3 |
2 |
0 |
3 |
1 |
1 |
|
| Unknown |
23 |
1 |
5 |
2 |
4 |
|
|
Tumor size classification (n) | ||||||
| <4 cm |
20 |
0 |
5 |
0 |
0 |
n.s. |
| 4-7 cm |
48 |
1 |
19 |
3 |
2 |
|
| >7 cm |
119 |
10 |
40 |
5 |
5 |
|
| Unknown |
9 |
0 |
2 |
0 |
4 |
|
|
Perinephric fat invasion (n) | ||||||
| No |
86 |
3 |
20 |
5 |
0 |
p < 0.05: surgical category 1 vs. surgical category 2, 3 |
| Yes |
22 |
4 |
16 |
1 |
0 |
|
| Unknown |
88 |
4 |
30 |
2 |
11 |
|
|
Tumor nuclear grade (n) | ||||||
| G1 |
18 |
1 |
5 |
3 |
0 |
n.s. |
| G2 |
129 |
7 |
42 |
1 |
0 |
|
| G3 |
48 |
3 |
19 |
4 |
0 |
|
| Unknown |
1 |
0 |
0 |
0 |
11 |
|
|
Histopathologic category (n) | ||||||
| Clear cell |
144 |
10 |
48 |
4 |
0 |
p < 0.05; : surgical category 1, 2, 3, 4 vs. surgical category 5 surgical category 3 vs. surgical category 4 |
| Papillary, chromophobe, others |
42 |
1 |
14 |
1 |
9 |
|
| Spindle, sarcomatoid | 10 | 0 | 4 | 3 | 2 | |