Table 6.
Impact of follow-up duration on overall survival in patients with renal cell carcinoma extending into venous system: Multivariate logistic regression analyses using restricted follow-up data until 1, 2, and 3 years after intervention
| Variables | Estimate | ± | Standard error |
Odds ratio |
p value | |
|---|---|---|---|---|---|---|
| (95% Confident interval) | ||||||
|
Restricted follow-up until 1 year | ||||||
| Surgical category |
0.71 |
± |
0.19 |
2.03 |
(1.40-2.92) |
0.00016 |
| RV/IVC wall invasion status |
1.06 |
± |
0.39 |
2.87 |
(1.33-6.20) |
0.00721 |
| Tumor size |
0.69 |
± |
0.40 |
1.98 |
(0.91-4.34) |
0.08591 |
| Constant |
-4.15 |
± |
0.78 |
|
|
|
|
Restricted follow-up until 2 years | ||||||
| LDH |
2.48 |
± |
0.94 |
11.96 |
(1.91-75.0) |
0.00804 |
| Surgical category |
1.95 |
± |
0.52 |
7.04 |
(2.56-19.4) |
0.00016 |
| RV/IVC wall invasion status |
1.99 |
± |
0.79 |
7.28 |
(1.56-34.0) |
0.01152 |
| α2 globulin |
1.69 |
± |
0.80 |
5.44 |
(1.14-25.9) |
0.03351 |
| Constant |
-12.10 |
± |
2.86 |
|
|
|
|
Restricted follow-up until 3 years | ||||||
| LDH |
1.02 |
± |
0.49 |
2.78 |
(1.07-7.25) |
0.03621 |
| Surgical category |
0.86 |
± |
0.26 |
2.36 |
(1.42-3.92) |
0.00090 |
| α2 globulin |
1.62 |
± |
0.51 |
5.05 |
(1.84-13.8) |
0.00164 |
| Constant | -8.48 | ± | 1.75 | |||
In the stepwise multiple regression analysis, 3.2-10.5% α2 globulin, 66–288 U/l LDH, radical nephrectomy and complete resection of thrombus without metastasis in surgical category, <8.3-cm tumor size, and non-venous wall-invasive thrombus in RV/IVC wall invasion are coded as 1.
Similarly, 10.6-22.3% α2 globulin, 289–1740 U/l LDH, radical nephrectomy and complete resection of thrombus with metastases that has undergone a cytoreductive surgery in surgical category, 8.5-27.0-cm tumor size, and venous wall-invasive thrombus in RV/IVC wall invasion are coded as 2.
Radical nephrectomy and complete resection of thrombus with unresected metastases, radical nephrectomy and incomplete resection of thrombus regardless of metastatic status, and abandoned operation in surgical category are coded as 3, 4, and 5, respectively.