Table 1.
ZD6474 potentiates UV-B action on breast cancer cells
| Cell line | Treatment regimen | IC 50 (J/m 2 ) | PF a |
|---|---|---|---|
| MCF-7 |
UV-B |
101.20 ± 3.86 |
|
| UV-B + ZD6474 |
59.20 ± 2.45 |
1.71 |
|
| ZR-75-1 |
UV-B |
74.21 ± 4.01 |
|
| UV-B + ZD6474 |
41.26 ± 3.01 |
1.80 |
|
| MDA-MB-468 |
UV-B |
32.54 ± 2.67 |
|
| UV-B + ZD6474 |
12.17 ± 2.49 |
2.67 |
|
| MDA-MB-231 |
UV-B |
35.33 ± 1.23 |
|
| UV-B + ZD6474 |
15.12 ± 2.12 |
2.34 |
|
| T-47D |
UV-B |
42.12 ± 2.12 |
|
| UV-B + ZD6474 |
25.21 ± 2.12 |
1.67 |
|
| HMEpC |
UV-B |
250.72 ± 9.12 |
|
| UV-B + ZD6474 | 248.12 | 1.01 |
aPotentiation Factor (PF) indicates a quantitative measure of fold-sensitivity of UV-B radiation treated with 1 μM ZD6474 at a given effect compared with the sensitivity of UV-B alone.