Figure 5.

Inhibition of ovariectomy-induced decrease in bone mineral density and bone mineral content by SWT extract. (A) Female ICR mice were given a sham operation or were ovariectomized. Mice that underwent ovariectomy were treated with the indicated concentrations of SWT extract by oral feeding. Total body bone mineral density (A), bone mineral content (B), serum ALP activity (C), serum BMP-2 (D), serum OPN (E), and serum C-terminal telopeptides of type I collagen (F), were determined 4 wks after surgery. Data are presented as mean ± SEM (n = 8–10 mice/group). *, p < 0.05 compared to sham; #, p < 0.05 compared to the ovariectomized group.