Table 5.
Copy number variations of mtDNA in late-stage gastric cancer — univariate associations with clinicopathological characteristics
| Characteristics |
Copy number <3.61 |
|
Copy number >5.35 |
|
|---|---|---|---|---|
| OR * (95% CI) | P | OR * (95% CI) | P | |
| Male vs. Female |
1.57 (0.31-7.99) |
0.59 |
2.79 (0.37-20.82) |
0.32 |
| Age1 |
0.67 (0.15-2.89) |
0.59 |
1.33 (0.25-7.01) |
0.73 |
| Tumor localization2 |
0.44 (0.13-1.45) |
0.18 |
0.70 (0.19-2.616) |
0.60 |
| Tumor size3 |
1.86 (0.78-4.42) |
0.16 |
2.10 (0.79-5.57) |
0.14 |
| Tumor invasion4 |
1.13 (0.53-2.41) |
0.74 |
1.16 (0.50-2.69) |
0.73 |
| Lymph node metastasis |
27.00 (2.89-252.62) |
0.004 |
13.50 (1.34-135.98) |
0.03 |
| Survival status5 | 3.11 (0.66-14.60) | 0.15 | 6.42 (1.09-37.74) | 0.04 |
*OR: odds ratio with 95% confidence interval; 1Age (per 10 years); 2Tumor localization (gastric cardia; gastric body; gastric antrum); 3Tumor size (≤3 cm; >3 cm and ≤5 cm; >5 cm); 4Tumor invasion (T1; T2; T3; T4); 5Survival status (Alive vs. Dead). The cases with 3.61-5.35 mtDNA copies were used as reference.