Table 7.
Prognostic value of clinicopathological factors and copy number variation of mtDNA in univariate and multivariate Cox regression analysis (n=103)
| |
Univariate analysis |
Multivariate analysis |
||
|---|---|---|---|---|
| Variable | Hazard ratio (95% CI) | P | Hazard ratio (95% CI) | P |
| Copy number |
|
|
|
|
| 3.61~5.35 |
1.00 (reference) |
|
1.00 (reference) |
|
| <3.61 |
1.51 (0.44-2.57) |
0.90 |
0.52 (0.20-1.38) |
0.19 |
| >5.35 |
1.53 (0.58-4.02) |
0.39 |
1.07 (0.37-3.07) |
0.90 |
| The number of lymph node metastasis |
|
|
|
|
| 0 |
1.00 (reference) |
|
1.00 (reference) |
|
| 1~6 |
6.86 (3.18-14.91) |
<0.001 |
7.28 (2.87-18.49) |
<0.001 |
| 7~15 |
6.41 (2.70-15.25) |
<0.001 |
4.68 (1.65-13.28) |
0.004 |
| ≥16 |
16.75 (5.05-55.56) |
<0.001 |
13.21 (3.33-52.45) |
<0.001 |
| Tumor invasion |
|
|
|
|
| T1 |
1.00 (reference) |
|
1.00 (reference) |
|
| T2 |
0.85 (0.16-4.67) |
0.86 |
0.63 (0.11-3.54) |
0.60 |
| T3 |
4.36 (1.53-12.42) |
0.006 |
1.51 (0.46-4.92) |
0.49 |
| T4 |
2.66 (1.30-5.48) |
0.001 |
3.33 (0.92-12.14) |
0.07 |
| Differentiation |
|
|
|
|
| Well/moderate |
1.00 (reference) |
|
1.00 (reference) |
|
| Poor/undifferentiation | 2.22 (1.19-4.19) | 0.01 | 1.82 (0.86-3.82) | 0.12 |