Figure 1.

Serial measurements of serum osteocalcin (a), alkaline phosphatase (ALP) (b) and bone-specific alkaline phosphatase (BAP) (c) from 5 FOP patients. Serum levels of osteocalcin were maintained within the normal range during the study period in all patients. Serum levels of ALP rapidly elevated at M-9 m in Cases 2 and 3 who showed acute flare-ups at M-7 m and M-8 m, respectively. Case 3, who showed acute inflammation of her right jaw at D-2 m, had persistent higher ALP levels at D-3 m. Changes in serum BAP activity positively correlated to those in serum ALP levels.