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. 2013 Oct 16;8:163. doi: 10.1186/1750-1172-8-163

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Copyright © 2013 Kitoh et al.; licensee BioMed Central Ltd.

This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Volumetric computed tomography (CT) examination. Representative reconstructed 3D-CT image obtained by whole body scanning of Case 1 (a), and changes in total bone volume within the region of interests (ROI) in each FOP patient (b). In Case 2, total bone volume has increased 223 cm³ and 155 cm³ during the medication and discontinuation phases, respectively. In Case 3, there was an increase of 297 cm³ and 536 cm³ in the total bone volume during the medication and discontinuation phases, respectively.