Table 6.
Cat | Study | NMZ | NDZ | Age | Heritability | Variance of A | Variance of E Baseline and AxE parameter | Variance of C | χ2(1) | ||
---|---|---|---|---|---|---|---|---|---|---|---|
| |||||||||||
mean | sd | h2 | σA2 | β0 (baseline) | β1 (AxE) | σC2 | |||||
4–10 | Netherlands #1 | 125 | 112 | 5.80 | 0.06 | 0.43 | 0.42 (0.18; 0.68) | −1.43 (−1.77; −1.13) | −0.70 (−1.09; −0.34) | 0.26 (0.03; 0.50) | 14.62 |
Netherlands #2 | 49 | 63 | 9.10 | 0.10 | 0.53 | 0.52 (0.18; 0.98) | −1.54 (−1.92; −1.11) | −0.16 (−0.64; 0.29) | 0.24 (0.00; 0.60) | 0.53 | |
Colorado #1 | 391 | 534 | 8.92 | 0.80 | 0.64 | 0.65 (0.51; 0.84) | −1.82 (−2.04; −1.59) | 0.42 (−0.17; 0.68) | 0.19 (0.05; 0.32) | 2.65 | |
Ohio | 121 | 171 | 6.07 | 0.68 | 0.42 | 0.42 (0.21; 0.65) | −1.46 (−1.71; −1.20) | 0.13 (−0.19; 0.46 | 0.34 (0.12; 0.55) | 0.62 | |
UK | 394 | 714 | 10.59 | 0.24 | 0.32 | 0.32 (0.18; 0.46) | −1.21 (−1.37; −1.06) | −0.53 (−0.72; −0.37) | 0.34 (0.22; 0.45) | 42.52 | |
| |||||||||||
Aggregated | 1140 | 1616 | 9.06 | 1.79 | 0.42 | 0.41 (0.34; 0.49) | −1.42 (−1.52; −1.33) | −0.33 (−0.45; −0.22) | 0.34 (0.26; 0.41) | 33.98 | |
| |||||||||||
11–13 | Netherlands #3 | 79 | 111 | 12.02 | 0.08 | 0.64 | 0.64 (0.41; 0.87) | −1.95 (−2.25; −1.62) | −0.02 (−0.49; 0.51) | 0.21 (0.00; 0.47) | 0.01 |
Colorado #1 | 204 | 280 | 11.85 | 0.81 | 0.65 | 0.64 (0.50; 0.80) | −2.06 (−2.26; −1.85) | 0.14 (−0.13; 0.43) | 0.22 (0.08; 0.38) | 1.01 | |
Minnesota #1 | 734 | 453 | 11.82 | 0.40 | 0.49 | 0.49 (0.36; 0.62) | −1.44 (−1.55; −1.33) | 0.23 (−0.001; 0.42) | 0.27 (0.14; 0.40) | 3.82 | |
UK | 1135 | 1818 | 11.78 | 0.40 | 0.50 | 0.49 (0.41; 0.57) | −1.37 (−1.47; −1.28) | −0.73 (−0.83; −0.64) | 0.16 (0.09; 0.23) | 306.29 | |
| |||||||||||
Aggregated | 2195 | 2720 | 11.83 | 0.47 | 0.56 | 0.52 (0.46; 0.59) | −1.45 (−1.52; −1.38) | −0.52 (−0.60; −0.45) | 0.21 (0.15; 0.27) | 203.10 | |
| |||||||||||
14–16 | Colorado #1 | 126 | 173 | 14.74 | 0.77 | 0.80 | 0.79 (0.63; 0.93) | −2.12 (−2.36; −1.86) | 0.09 (−0.26; 0.46) | 0.08 (0.02; 0.26) | 0.27 |
Colorado #2 | 153 | 125 | 16.00 | 0.00 | 0.75 | 0.76 (0.49; 0.96) | −2.03 (−2.31; −1.76) | 0.57 (0.25; 0.93) | 0.10 (0.02; 0.36) | 11.58 | |
Colorado #3 | 99 | 140 | 14.75 | 0.84 | 0.54 | 0.54 (0.28; 0.81) | −1.54 (−1.97; −1.21) | −0.33 (−0.95; 0.12) | 0.24 (0.00; 0.50) | 1.89 | |
Minnesota #2 | 92 | 31 | 16.84 | 0.10 | 0.81 | 0.77 (0.62; 0.93) | −1.70 (−1.95; −1.42) | 0.19 (−0.16; 0.52) | 0.00 (0.00; 0.34) | 1.13 | |
Australia | 324 | 483 | 15.93 | 0.26 | 0.73 | 0.72 (0.59; 0.82) | −1.75 (−1.91; −1.59) | −0.24 (−0.45; −0.03) | 0.09 (0.02; 0.22) | 5.12 | |
| |||||||||||
Aggregated | 807 | 966 | 15.66 | 0.81 | 0.71 | 0.71 (0.63; 0.78) | −1.77 (−1.86; −1.67) | −0.05 (−0.20; 0.10) | 0.12 (0.06; 0.20) | 0.41 | |
| |||||||||||
17–34 | Netherlands #4 | 66 | 94 | 17.62 | 0.38 | 0.80 | 0.85 (0.62; 1.00) | −1.93 (−2.28; −1.55) | −0.11 (−0.53; 0.35) | 0.06 (0.00; 0.23) | 0.24 |
Colorado #3 | 203 | 180 | 19.46 | 2.00 | 0.53 | 0.53 (0.36; 0.73) | −1.85 (−2.11; −1.61) | −0.38 (−0.74; −0.05) | 0.31 (0.11; 0.50) | 4.94 | |
Minnesota #2 | 318 | 183 | 17.63 | 0.36 | 0.57 | 0.56 (0.38; 0.76) | −1.76 (−1.97; −1.57) | 0.53 (0.27; 0.82) | 0.23 (0.07; 0.43) | 17.21 | |
| |||||||||||
Aggregated | 700 | 615 | 18.78 | 2.71 | 0.69 | 0.69 (0.57; 0.80) | −1.77 (−1.88; −1.65) | 0.19 (0.01; 0.37) | 0.14 (0.05; 0.26) | 4.39 |
Note. χ2(1) denotes a likelihood ratio test on parameter β1. 95% confidence intervals are in brackets.
In a few cases we experienced numerical difficulties in estimating the lower bound of γ0 because the number of DZ twins was too small. ‘Aggregated’ is based on the aggregated data within the corresponding age category including the Netherlands #5 and Netherlands #6 studies. As some samples are omitted in the analysis of the individual studies (see Table 2), NMZ and NDZ will not necessarily add up to the aggregated NMZ and NDZ.