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. 2014 Mar 7;13:50. doi: 10.1186/1476-4598-13-50

Figure 1.

Figure 1

Compound structures and cell binding characteristics of SW IV-134. (A) The chemical structures of sigma-2 ligand SW43, the SMAC peptidomimetic SW IV-52, and the chemical conjugate SW IV-134. Note that the chirality of SW IV-52 is fully retained in the drug conjugate (asterisks). (B) SW IV-134 prevents uptake of the fluorescently labeled sigma-2 ligand SW120 in a dose-dependent fashion. SKOV3 cells were pretreated with increasing concentration of SW IV-134, followed by incubation with SW120, prior to analysis by flow cytometry.