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Conjugation of the SMAC mimetic SW IV-52 to SW43 significantly enhances the killing potential of the individual components. (A) SKOV3, (B) OVCAR3 (C) HEY A8 and (D) HEY A8 MDR cells were treated with increasing doses of SW43, SW IV-52, SW43 plus SW IV-52, and SW IV-134 for 18 hours. Cell viability was determined by CellTiter-Glo assays [p < 0.015 (A), NS (B), p < 0.017 (C), p < 0.034 (D), one-way ANOVA].
