Table 3.
A summary of in vitro IC 50 of Flavokawain A, B, C in selected cancer cell lines
| Flavokawain | Cancer cell lines | IC 50 μM |
|---|---|---|
|
Flavokawain A |
T24 |
~17 |
| RT4 |
~17 |
|
| EJ |
~17 |
|
| L-02 |
n.c. |
|
| HepG2 |
n.c. |
|
|
Flavokawain B |
KB |
20.05 ± 0.4 |
| MCF-7 |
49.30 ± 1.8 |
|
| Ca Ski |
31.10 ± 1.3 |
|
| HCT116 |
~25 |
|
| A549 |
~25 |
|
| HFW |
~25 |
|
| NIH3T3 |
~25 |
|
| MRC5 |
17.2 ± 0.5 |
|
| T24 |
4.39-8.80 |
|
| RT4 |
~18 |
|
| EJ |
~9-18 |
|
| LAPC4 |
32 |
|
| LNCaP |
48.3 |
|
| PC-3 |
6.20 |
|
| DU145 |
3.90 |
|
| WPMY-1 |
2.25 |
|
| 22RV1 |
16.6 |
|
| C4-2B |
2.2 |
|
| L-02 |
35.15 ± 2.56 |
|
| HepG2 |
62.38 ± 5.04 |
|
| HSC-3 |
~18 |
|
| Cal-27 |
~27 |
|
| A-2058 |
~18 |
|
| SYO |
~9-18 |
|
| HS-SY-II |
~18-27 |
|
| H460 |
18.2 |
|
| ACC-2 |
4.69 ±0.43 |
|
| T24 |
~8-17 |
|
| Flavokawain C | RT4 |
~1.5-17 |
| EJ |
~8.33 |
|
| L-02 |
57.04 ± 2.32 |
|
| HepG2 | 59.48 ± 2.72 |